Skip to contentWatch LiveNewsWeatherSportsVideosContact UsInterstate 22 crash in Tupelo, MS on Sept. 11, 2026(WTVA)Published: Sep. 11, 2026 at 3:28 PM EDT|Updated: 6 hours agoTUPELO, Miss. (WTVA) — A crash in Tupelo shut down a part of Interstate 22. The crash happened shortly after 2 p.m. on Friday near the Highway 45 interchange.Authorities temporarily closed both eastbound lanes. However, they reopened shortly before 3:00.Possible injuries are unknown at this time. Copyright 2026 WTVA. All rights reserved.Most ReadLatest News