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(https://x.com/intent/tweet?url=https%3A%2F%2Fwww.the-sun.com%2Fhealth%2F16961097%2Fdementia-reversed-breakthrough-surgery-flushes-toxic-brain-proteins&text=Dementia%20could%20be%20'REVERSED'%20as%20surgery%20'flushes%20out%20toxic%20proteins'%20from%20brain) Share on X (Opens in new window) X   (https://www.facebook.com/sharer.php?u=https%3A%2F%2Fwww.the-sun.com%2Fhealth%2F16961097%2Fdementia-reversed-breakthrough-surgery-flushes-toxic-brain-proteins&t=Dementia%20could%20be%20'REVERSED'%20as%20surgery%20'flushes%20out%20toxic%20proteins'%20from%20brain) Share on Facebook (Opens in new window) Facebook     (16961097.html#thesun-openweb-comments-container)   2 comments 2    A CONTROVERSIAL procedure that ‘replumbs’ the brain to ‘flush out toxic proteins’ could stop dementia in its tracks – or even reverse it – scientists claim.  (https://pmc.ncbi.nlm.nih.gov/articles/PMC12695186/) More than 2,000 people in China have undergone the experimental surgery, known as deep cervical lymphatic-venous anastomosis (dcLVA), to treat Alzheimer’s disease. (16961097.html#) (Open a slideshow of all 3 article images.) (NINTCHDBPICT001106329108)  3     The technique was pioneered by Qingping Xie (right), shown with surgeon Wei Chen (left) at the Cleveland Clinic Credit: ANQI XIE   (16961097.html#) (Open a slideshow of all 3 article images.) (Infographic depicting surprising early signs of dementia, including changes in humor, dressing scruffily, bad parking, swearing, giving out money, and having no filter.)  3     For people who experienced multiple falls, the risk increased to 74 per cent   Advertisement   A jaw dropping video of an 84-year-old dementia patient who underwent dcLVA in 2020 sparked “a  frenzy of this surgery being performed left and right”, according to (https://www.nature.com/articles/d41586-026-02448-x) Nature .  At first shown slumped and unresponsive in his hospital bed, subsequent clips show the man alert, walking and talking six months after the op.  Sign up for The US Sun newsletter   Thank you!    (thesuncom) (04351819b2)  (/health/16961097/)  (news) () Email address      Please provide a valid email.    (Sign up)   Your info will be used in accordance with our (https://newsprivacy.co.uk/) Privacy Policy   You'll now receive top stories, breaking news, and more, straight to your email.   (1)     It involves connecting tiny lymphatic vessels in the neck – part of the drainage system that carries waste away from the brain- to nearby veins, supposedly allowing fluid and waste proteins that cause dementia to flow more easily into the bloodstream. But the procedure, which at one point was being offered by hundreds of Chinese hospitals, was last year banned in settings outside of clinical studies, over concerns about the lack of evidence on safety and effectiveness.  Meanwhile, its pioneer – microsurgeon Qingping Xie, president of the Qiushi Hospital in Hangzhou – was detained by Chinese authorities in December for undisclosed reasons.  Now, studies utilising the technique are underway around the world.  More than 20 clinical trials under way on this surgery in China.  It’s also being investigated in the US and Singapore – where four people have had the operation. Advertisement   Most read in Health  (https://www.the-sun.com/health/11786613/boy-died-hay-fever-symptoms-cancer/) ()     BRAVE We thought son's stuffy nose was hay fever but he died - I'm honoring his last wish     (https://www.the-sun.com/health/16985032/first-west-nile-virus-death-california-cases-symptoms/) ()     SEVERE ILLNESS First human death from brain-swelling mosquito virus this year hits US state     (https://www.the-sun.com/health/12724981/sweat-ball-removed-mum-daughters-lump-bad-skin-clinic/) ()     SKIN DEEP Watch as giant 'SWEAT BALL' removed from mum's head and docs 'tease out fat lump'     (https://www.the-sun.com/health/16980720/binge-eating-left-me-33-st-shed-19-st/) (An image collage containing 2 images, Image 1 shows David John Castañeda before his 19-stone weight loss, Image 2 shows David John Castañeda posing shirtless in a bathroom mirror, showing his physique after significant weight loss)     'UNRECOGNISABLE' Binge eating left me weighing 33st - 5-word revelation helped me shed 19st        But dementia experts remain divided as to whether the surgery actually works.  Young-Kwon Hong, a lymphatics researcher at the Beth Israel Deaconess Medical Center in Boston, Massachusetts, told (https://www.nature.com/articles/d41586-026-02448-x) Nature : “The concept is scientifically valid and biologically plausible.” However, he added that he worries that “hype” around the technique has outpaced evidence. Meanwhile, Robert Howard, a professor of old age psychiatry at University College London, told the (https://www.dailymail.com/health/article-16093247/surgery-flush-toxic-proteins-reverse-dementia.html?ico=authors_pagination_desktop) Daily Mail that close examination of the data reveals the benefits of the surgery are tiny. The technique borrows from lymphatic venous anastomosis (LVA), a type of treatment that is already widely used on the NHS to tackle lymphoedema, swelling of the arms and legs due to a build-up of fluid. Advertisement   To carry out this procedure, surgeons make a tiny incision in a patient’s armpit before stitching the lymph vessel that’s full of fluid to a nearby vein – allowing the excess fluid to drain into the bloodstream. A similar process is followed for dcLVA, where surgeons make a small incision in the neck.  The surgeon then cuts into the deep cervical vein – which drains blood from the neck – and connects it to the lymphatic vessel  that runs alongside it.  The operation takes about two hours. It’s based on the premise that there are lymph vessels that are hidden plumbing keeping the brain clean.  Advertisement   (16961097.html#) (Open a slideshow of all 3 article images.) (The lymph supply of the neck)  3     It involves making an incision in the lymph vessels in the neck to supposedly clear the brain of toxic proteins Credit: Getty   The early stages of dementia  DEMENTIA is not a single condition. It is caused by different physical diseases of the brain – like Alzheimer’s, vascular dementia and DLB. More than 944,000 people in the UK currently have it. And no matter the type, it affects everyone differently. The first signs of it are often mild and easy to brush off, but can include: Memory problems (e.g. being unable to recall recent events or losing keys) Planning and thinking difficulties (e.g. finding complex decisions about finances hard) Language and communication trouble (e.g. struggling to find the right word) Poor orientation (e.g. getting lost easily in familiar areas) Visual-perceptual difficulties (e.g. problems judging distances) Changes in mood or emotion (e.g. feeling anxious or frightened or getting easily upset)  “Many people at the early stage of dementia stay largely independent and only need a bit of assistance with daily living,” Alzheimer’s UK says. “It is important to focus on what the person can do and not to take over and do things for them. “Instead, try doing things with them, for example helping the person develop a routine, reminder lists and prompts, and use technology.” Because dementia is progressive, it gets worse over time, usually over several years. Experts generally think of it in three stages: Early stage (mild) Middle stage (moderate) Late stage (severe)  “These stages can be used to understand how dementia is likely to change over time, and to help people prepare for the future,” the charity adds. “The stages also act as a guide to when certain treatments, such as medicines for Alzheimer’s disease, are likely to work best.” Most people who develop dementia are over the age of 65. Anyone diagnosed before this is considered to have young-onset dementia, which affects about 70,800 people in the UK.     If clogs in that plumbing contribute to disease, then fixing the flow might help to treat conditions like Alzheimer’s. The idea of flushing toxic proteins out of the brain also works similarly to blockbuster Alzheimer’s drugs such as lecanemab and donanemab.  However, these drugs aren’t available on the NHS as they were deemed to have limited benefits while causing dangerous side-effects like brain bleeds. In a new study conducted at Xi’an Fengcheng Hospital in Shaanxi, China, 83 patients with advanced dementia were operated upon.  Advertisement   Researchers claimed there were “significant” improvements to their condition. In the nine months after the surgery, there was a significant improvement in blood flow to the brain. Meanwhile, 40 per cent of the patients improved their scores on the Mini-Mental State Exam (MMSE), which measures attention, recall and language, after the surgery.  Writing in the Journal of Alzheimer’s Disease last month, the researchers said: “All the patients exhibited enhanced alertness and vitality, characterised by increased responsiveness and improved engagement. “Attention and executive functions [such as memory and planning] also significantly improved, enabling more effective interaction with caregivers.” Advertisement   Side-effects, they said, were mild, mostly involving temporary wound pain at the surgery site. But UK dementia experts remain sceptical.  Prof Howard said: “In the study, the MMSE scores increased from an average of 3.01 to just 4.45.” Thirty is the maximum.  “So even after surgery, these patients were still severely impaired by their dementia,” he added.  Advertisement   RECOMMENDED STORIES        “Also, everybody knew they were getting the real surgery, rather than a sham procedure, which means any increase is probably due to the placebo effect.” Even if the surgery does have a positive effect, he said, it may well be short-lived as whatever is driving the production of amyloid proteins has not been addressed. (16961097.html#thesun-openweb-comments-container)   2 comments 2      Topics (https://www.the-sun.com/topic/alzheimers/) Alzheimer's   (https://www.the-sun.com/topic/dementia/) Dementia   (https://www.the-sun.com/where/china/) China            YOU MIGHT LIKE             YOU MIGHT LIKE                                       RECOMMENDED FOR YOU              MORE FOR YOU              MORE FROM THE SUN (https://www.the-sun.com/health/11786613/boy-died-hay-fever-symptoms-cancer/) ()        (https://www.the-sun.com/health/11786613/boy-died-hay-fever-symptoms-cancer/)    BRAVE We thought son's stuffy nose was hay fever but he died - I'm honoring his last wish  A MUM whose son died from stage 3 cancer is now honouring his last wish to keep his memory alive.    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(https://www.the-sun.com/health/) Health    (https://www.the-sun.com/health/16980720/binge-eating-left-me-33-st-shed-19-st#thesun-openweb-comments-container)         (https://www.the-sun.com/health/16980720/binge-eating-left-me-33-st-shed-19-st/)                 (NINTCHDBPICT001106329108)   The technique was pioneered by Qingping Xie (right), shown with surgeon Wei Chen (left) at the Cleveland Clinic Credit: ANQI XIE   (Infographic depicting surprising early signs of dementia, including changes in humor, dressing scruffily, bad parking, swearing, giving out money, and having no filter.)   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